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技術文章

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當前位置:首頁技術文章現貨moradec AH-101-AF說明書

現貨moradec AH-101-AF說明書

更新時間:2022-12-28點擊次數:1088


現貨moradec AH-101-AF說明書

αHFc NC MMAF

抗人IgG Fc MMAF抗體與不可裂解連接子

目錄號:AH-101-AF

αHFc NC MMAF是一種抗人IgG Fc特異性抗體,其與單甲基auristatin F(MMAF)結合,具有不可裂解的接頭??贵w部分是對人IgG的Fc區特異的多克隆抗體。單甲基auristatin F(MMAF)是一種細胞毒性小分子,通過阻斷微管蛋白的聚合來抑制細胞分裂。連接MMAF和抗體的不可裂解接頭在細胞外液中是穩定的,但在進入細胞時可以通過未指明的機制裂解。




αHFc-NC-MMAF


Anti-human IgG Fc-MMAF Antibody with Non-Cleavable Linker

Catalog Number: AH-101-AF

αHFc-NC-MMAF is anti-human IgG Fc specific antibody conjugated to monomethyl auristatin F (MMAF) with a non-cleavable linker. The antibody portion is a polyclonal antibody which is specific to the Fc region of human IgGs. Monomethyl auristatin F (MMAF) is a cytotoxic small molecule which inhibits cell division by blocking the polymerization of tubulin. The non-cleavable linker connecting MMAF to the antibody is stable in extracellular fluid, but can be cleaved by unspecified mechanisms upon entering cells.