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技術文章

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當前位置：首頁技術文章現貨moradec AH-102-DD說明書

現貨moradec AH-102-DD說明書

更新時間：2022-12-28點擊次數：1330



現貨moradec AH-102-DD說明書

αHFc CL PNU

抗人IgG Fc-PNU159682抗體

目錄號：AH-102-DD

αHFc CL PNU是與PNU-159268結合的抗人IgG Fc特異性抗體，具有可裂解接頭。抗體部分是對人IgG的Fc區特異的多克隆抗體。PNU-159682是內柔比星的衍生物，是一種細胞毒性小分子，通過插入DNA和抑制復制導致細胞死亡。連接PNU-159682與抗體的可裂解接頭在細胞外液中是穩定的，但一旦綴合物通過內吞作用進入細胞，則被內體中的組織蛋白酶裂解。




αHFc-CL-PNU


Anti-human IgG Fc-PNU159682 Antibody with Cleavable Linker

Catalog Number: AH-102-DD

αHFc-CL-PNU is anti-human IgG Fc specific antibody conjugated to PNU-159268 with a cleavable linker. The antibody portion is a polyclonal antibody which is specific to the Fc region of human IgGs. PNU-159682, a derivative of nemorubicin, is a cytotoxic small molecule which causes cell death by intercalating DNA and inhibiting replication. The cleavable linker connecting PNU-159682 to the antibody is stable in extracellular fluid, but is cleaved by cathepsin in endosome once the conjugate has entered a cell via endocytosis.